Tóm tắt

Objectives: To describe the quality of cord blood stem cell stored in Stem Cell Bank of National Institute of Hematology and Blood Transfusion, to assess the initial results of cord blood transplantation for acute leukemia treatment. Subjects and method: Interventional, retrospective and prospective study. Subjects included 3,466 public cord blood units which were successfully stored, 05 patients with acute leukemia, transplanted by cord blood stem cell, in National Institute of Hematology and Blood Transfusion, from October of 2016 to September of 2018. Results: After 02 years of following up, among 3,466 stored public cord blood units, the mean total nucleated cell was 130.4 ± 41.9 x 107, the mean CD34 cell was 45.9 ± 35.5 x 105, the post-thawed viability of stem cells was 84.7 ± 3.4%; there were 30 acute leukemia patients who were indicated for stem cell searching in public cord blood bank and the rate of successful search was 97.7%; 05 patients were transplanted using the matched stem cell units; among that, 02 patients achieved stable engraftment; the most common complications were mucosal ulceration (100%), bacteremia (100%) and CMV reactivation (100%); graft versus host disease happened in 01 case; 03 mortality cases were all due to severe sepsis. Conclusion: Allogeneic cord blood transplantation is a promising and effective method for the treatment of acute leukemia. * Keywords: Acute leukemia; Allogeneic; Stem cell transplantation; Cord blood; Stem cell.

Abstract

Objectives: To describe the quality of cord blood stem cell stored in Stem Cell Bank of National Institute of Hematology and Blood Transfusion, to assess the initial results of cord blood transplantation for acute leukemia treatment. Subjects and method: Interventional, retrospective and prospective study. Subjects included 3,466 public cord blood units which were successfully stored, 05 patients with acute leukemia, transplanted by cord blood stem cell, in National Institute of Hematology and Blood Transfusion, from October of 2016 to September of 2018. Results: After 02 years of following up, among 3,466 stored public cord blood units, the mean total nucleated cell was 130.4 ± 41.9 x 107, the mean CD34 cell was 45.9 ± 35.5 x 105, the post-thawed viability of stem cells was 84.7 ± 3.4%; there were 30 acute leukemia patients who were indicated for stem cell searching in public cord blood bank and the rate of successful search was 97.7%; 05 patients were transplanted using the matched stem cell units; among that, 02 patients achieved stable engraftment; the most common complications were mucosal ulceration (100%), bacteremia (100%) and CMV reactivation (100%); graft versus host disease happened in 01 case; 03 mortality cases were all due to severe sepsis. Conclusion: Allogeneic cord blood transplantation is a promising and effective method for the treatment of acute leukemia. * Keywords: Acute leukemia; Allogeneic; Stem cell transplantation; Cord blood; Stem cell.