Tóm tắt

Background: Neuroblastoma is the most common extracranial solid cancer of childhood and is characterized by a remarkable biological heterogeneity, cause multiple genetic changes. The genetic profiles are the powerful tools for the clinician in risk stratification and treatment tailoring in neuroblastoma patients. This will increase the chance of treatment’s success and minimize the dose of chemotherapy for these patients. Subjects: 6 neuroblastoma patients under 18 months, non-amplified MYCN were diagnosed and treated in National Children’s Hospital. Method: The CGH technique is performed on the Agilent’s system with the 400k chip at Vinmec International Hospital. Results: 4 patients were found the numerical chromosomal abnormalities (both stage L2), the others were the segmental chromosomal abnormalities (1 stage L2 and 1 stage M). Based on this results, 4/5 patients could be stopped the chemotherapy, 1 patient had to continue the treatment. The stage M patient had the 50% of chance of success in high-dose chemotherapy and stem cell transplantation. Conclusion: The genomic profile by CGH is established successfully in Vietnam. The integration of this technique allows more precise prognostication and refined treatment assignment which contribute to improve survival with decreased toxicity. * Keywords: Neuroblastoma; Genomic hybridization.

Abstract

Background: Neuroblastoma is the most common extracranial solid cancer of childhood and is characterized by a remarkable biological heterogeneity, cause multiple genetic changes. The genetic profiles are the powerful tools for the clinician in risk stratification and treatment tailoring in neuroblastoma patients. This will increase the chance of treatment’s success and minimize the dose of chemotherapy for these patients. Subjects: 6 neuroblastoma patients under 18 months, non-amplified MYCN were diagnosed and treated in National Children’s Hospital. Method: The CGH technique is performed on the Agilent’s system with the 400k chip at Vinmec International Hospital. Results: 4 patients were found the numerical chromosomal abnormalities (both stage L2), the others were the segmental chromosomal abnormalities (1 stage L2 and 1 stage M). Based on this results, 4/5 patients could be stopped the chemotherapy, 1 patient had to continue the treatment. The stage M patient had the 50% of chance of success in high-dose chemotherapy and stem cell transplantation. Conclusion: The genomic profile by CGH is established successfully in Vietnam. The integration of this technique allows more precise prognostication and refined treatment assignment which contribute to improve survival with decreased toxicity. * Keywords: Neuroblastoma; Genomic hybridization.