Tóm tắt

Background: Glioblastoma is the most prevalence primary malignant brain tumor, which takes up 16% of all primary brain and central nervous system malignancy. Molecular variations or gene expression patterns have also been recognized in primary and secondary glioblastomas. Genetic typical alterations for primary glioblastoma are epidermal growth factor receptor and fibroblast growth factor receptors variations. Subjects and methods: We recruited 60 patients diagnosed with primary glioblastoma in which biopsy samples were collected to assess for FGFR and EGFR mutations. Results and conclusion: 6/60 patients (8.3%) were positive with FGFR mutation (p.R576W, p.A575V, p.N546K). 8/60 patients (13.3%) were identified with EGFR, a total of 7 mutations were identified p.P272S, p.G42D, p.T274M, p.K293X, p.L62I, p.G42D, p.A289T. This is the first study on FGFR and EGFR mutation in glioblastoma patients in Vietnam. The results would contribute to better understanding the pathological and molecular mechanism of glioblastoma in Vietnam. * Keywords: Glioblastoma; EGFR; FGFR; Mutation analysis.

Abstract

Background: Glioblastoma is the most prevalence primary malignant brain tumor, which takes up 16% of all primary brain and central nervous system malignancy. Molecular variations or gene expression patterns have also been recognized in primary and secondary glioblastomas. Genetic typical alterations for primary glioblastoma are epidermal growth factor receptor and fibroblast growth factor receptors variations. Subjects and methods: We recruited 60 patients diagnosed with primary glioblastoma in which biopsy samples were collected to assess for FGFR and EGFR mutations. Results and conclusion: 6/60 patients (8.3%) were positive with FGFR mutation (p.R576W, p.A575V, p.N546K). 8/60 patients (13.3%) were identified with EGFR, a total of 7 mutations were identified p.P272S, p.G42D, p.T274M, p.K293X, p.L62I, p.G42D, p.A289T. This is the first study on FGFR and EGFR mutation in glioblastoma patients in Vietnam. The results would contribute to better understanding the pathological and molecular mechanism of glioblastoma in Vietnam. * Keywords: Glioblastoma; EGFR; FGFR; Mutation analysis.