Tóm tắt

Objectives: To optimize formulation of curcumin solid dispersion (CSD). Methods: Prepare curcumin solid dispersion using spray drying method and apply Modde 7.0 software to design the experiments and optimize the formulations. Results: The optimal formulation to prepare curcumin solid dispersion system using spray drying method including: ratio of curcumin: PVP K30 (1:8.8, w/w) composed 0.76% of lutrol F127 and 3.85% aerosil. With this optimal formulation, the solubility of curcumin was 6942.47g/L and the dissolution reached 100% in period of 30 minutes. Conclusion: The optimal formulation for preparing curcumin solid dispersion system using spray drying method was established that is potential to enhance bioavaibility of this active component. * Key words: Curcumin solid dispersion; Spray drying method; Optimization; Experimental design.

Abstract

Objectives: To optimize formulation of curcumin solid dispersion (CSD). Methods: Prepare curcumin solid dispersion using spray drying method and apply Modde 7.0 software to design the experiments and optimize the formulations. Results: The optimal formulation to prepare curcumin solid dispersion system using spray drying method including: ratio of curcumin: PVP K30 (1:8.8, w/w) composed 0.76% of lutrol F127 and 3.85% aerosil. With this optimal formulation, the solubility of curcumin was 6942.47g/L and the dissolution reached 100% in period of 30 minutes. Conclusion: The optimal formulation for preparing curcumin solid dispersion system using spray drying method was established that is potential to enhance bioavaibility of this active component. * Key words: Curcumin solid dispersion; Spray drying method; Optimization; Experimental design.