Tóm tắt

Objectives: Adipose tissue-derived hormones are associated with metabolic disorders including type 2 diabetes mellitus (T2DM). This study investigated clinical parameters and the levels of leptin cytokine in patients with T2DM with or without overweight/obese. Materials and methods: Based on body mass index (BMI), 130 patients with T2DM were divided either as overweight/obese or non-overweight/non-obese subjects. 125 overweight/obese and nonoverweight/non-obese individuals devoid of T2DM were included as healthy controls. The leptin levels were measured in the plasma samples in all study subjects by ELISA and clinical parameters. Results: The leptin levels were significantly lower in patients with T2DM compared to controls ([1202.75 pg/ml median vs. 1715.4 pg/ml], p = 0.05). The leptin levels were increased in overweight/obese T2DM patients and in overweight/obese healthy subjects compared to without overweight/obese T2DM patients and healthy induviduals (p < 0.05). The levels of leptin were significantly increased in female patients with T2DM and in T2DM patients with metabolic syndrome (MS) compared to those of male patients (p < 0.001) and T2DM patients with none-MS (p < 0.05). Conclusions: Leptin cytokine is associated with T2DM and may serve as a prognostic marker for overweight/obese-related T2DM. * Keywords: Type 2 diabetes mellitus; Overweight; Obesity; Leptin; Insulin.

Abstract

Objectives: Adipose tissue-derived hormones are associated with metabolic disorders including type 2 diabetes mellitus (T2DM). This study investigated clinical parameters and the levels of leptin cytokine in patients with T2DM with or without overweight/obese. Materials and methods: Based on body mass index (BMI), 130 patients with T2DM were divided either as overweight/obese or non-overweight/non-obese subjects. 125 overweight/obese and nonoverweight/non-obese individuals devoid of T2DM were included as healthy controls. The leptin levels were measured in the plasma samples in all study subjects by ELISA and clinical parameters. Results: The leptin levels were significantly lower in patients with T2DM compared to controls ([1202.75 pg/ml median vs. 1715.4 pg/ml], p = 0.05). The leptin levels were increased in overweight/obese T2DM patients and in overweight/obese healthy subjects compared to without overweight/obese T2DM patients and healthy induviduals (p < 0.05). The levels of leptin were significantly increased in female patients with T2DM and in T2DM patients with metabolic syndrome (MS) compared to those of male patients (p < 0.001) and T2DM patients with none-MS (p < 0.05). Conclusions: Leptin cytokine is associated with T2DM and may serve as a prognostic marker for overweight/obese-related T2DM. * Keywords: Type 2 diabetes mellitus; Overweight; Obesity; Leptin; Insulin.