Tóm tắt

Terbinafine - an allylamine drug has been shown to be fungicidal against dermatophytes and has been approved by Vietnam’s Ministry of Health for treating dermatophytosis, but no study on evaluating its effect and safety has been done in Vietnam. Objective: To evaluate the efficacy and safety of the drug in the treatment of tinea. Subjects and methods: 29 patients with mild, moderate lesions of ringworm take topical terbinafine 1% for 2 - 4 weeks (group 1); 27 patients with extensive tinea or respond poorly to topical treatment take a combination of topical and oral terbinafine for 1 - 14 days (group 2). Clinical and mycological assessments were made at 2 and 4 weeks after starting treatment. Results: The clinical cure after 2 weeks was 73.21% and mycological cure was 85.71%; complete cure was 68.76%. The rate of complete cure in group 1 (82.76%) was higher than group 2 (50%; p < 0.05). 4 weeks after treatment, all patients were cured completely. Patients taking only topical medication did not have undesirable effects. Some patients in group 2 experienced side effects such as nausea (25.93%); flatulence (3.70%) and dizziness (40.74%). Conclusion: Terbinafine is effective and safe in the treatment of ringworm. * Key words: Ringworm; Terbinafine; Efficacy; Safety.

Abstract

Terbinafine - an allylamine drug has been shown to be fungicidal against dermatophytes and has been approved by Vietnam’s Ministry of Health for treating dermatophytosis, but no study on evaluating its effect and safety has been done in Vietnam. Objective: To evaluate the efficacy and safety of the drug in the treatment of tinea. Subjects and methods: 29 patients with mild, moderate lesions of ringworm take topical terbinafine 1% for 2 - 4 weeks (group 1); 27 patients with extensive tinea or respond poorly to topical treatment take a combination of topical and oral terbinafine for 1 - 14 days (group 2). Clinical and mycological assessments were made at 2 and 4 weeks after starting treatment. Results: The clinical cure after 2 weeks was 73.21% and mycological cure was 85.71%; complete cure was 68.76%. The rate of complete cure in group 1 (82.76%) was higher than group 2 (50%; p < 0.05). 4 weeks after treatment, all patients were cured completely. Patients taking only topical medication did not have undesirable effects. Some patients in group 2 experienced side effects such as nausea (25.93%); flatulence (3.70%) and dizziness (40.74%). Conclusion: Terbinafine is effective and safe in the treatment of ringworm. * Key words: Ringworm; Terbinafine; Efficacy; Safety.