Tóm tắt

Objectives: The present study uses immune-deficient mice model bearing human colon cancer to investigate the change of the rate of immune cells which play a key role in cancer treatment by treating complex oncolytic virus (OLV) Measle/Mump. Subject and methods: Nude mice was divided into 4 groups: control group, measle virus-treated group, mump virus-treated group and complex Measle/Mump virus-treated group with dose of 106 CFU/individual for single injection. Population of macrophage, dendritic cell, NK cell in nude mice’s spleen were analyzed by flow cytometry method. Results: The results showed differences between groups: the rate of immune cells in treated groups were clearly increased compared to control group while complex OLV-treated group had a higher rate of immune cells than single OLV-treated groups. Conclusion: Using complex OLV bring a significant effects on stimulating immune response more than using single OLV. * Key words: Colon cancer; Oncolytic virus Measle/Mump; Immune response; Nude mice.

Abstract

Objectives: The present study uses immune-deficient mice model bearing human colon cancer to investigate the change of the rate of immune cells which play a key role in cancer treatment by treating complex oncolytic virus (OLV) Measle/Mump. Subject and methods: Nude mice was divided into 4 groups: control group, measle virus-treated group, mump virus-treated group and complex Measle/Mump virus-treated group with dose of 106 CFU/individual for single injection. Population of macrophage, dendritic cell, NK cell in nude mice’s spleen were analyzed by flow cytometry method. Results: The results showed differences between groups: the rate of immune cells in treated groups were clearly increased compared to control group while complex OLV-treated group had a higher rate of immune cells than single OLV-treated groups. Conclusion: Using complex OLV bring a significant effects on stimulating immune response more than using single OLV. * Key words: Colon cancer; Oncolytic virus Measle/Mump; Immune response; Nude mice.