Tóm tắt

A study on the rate and some risk factors causing gene EGFR mutation in lung adenocarcinoma was conducted at Bachmai Hospital. Objectives: To determine the rate and risk factors for EGFR gene mutations on 152 patients with lung adenocarcinoma at Bachmai Hospital. Subjects and methods: 152 patients with lung adenocarcinoma diagnosed by histopathological method; the mutation of EGFR gene was identified by assay Strip methods. Results: 60 lung cancer patients (39.5%) were diagnosed adenocarcinoma. The rate of mutations was found at exons 18, 19, 20, 21 of the EGFR gene. The exon mutations were classified as follows: G719S mutation, G719C (exon 18), LREA deletion (exon 19), T790M (exon 20) and L858R; L861Q (exon 21) were 3.2%, 55.6%, 4.8% and 36.4%, respectively. The possibility of EGFR gene mutations in female patients was 2.9 times as high as male patients (95%CI 1.4 to 6.1) and 3.4 fold higher compared to patients with history of smoking with 95%CI: 1.6 to 6.2. Conclusions: Among 152 patients with lung adenocarcinoma who were treated at Bachmai Hospital, we found the rate of EGFR gene mutations was 39.5%. The mutations of EGFR gene were more common in women and non-smoking patients. * Key words: Lung adenocarcinoma; EGFR gene mutation; Gender; Smoking.

Abstract

A study on the rate and some risk factors causing gene EGFR mutation in lung adenocarcinoma was conducted at Bachmai Hospital. Objectives: To determine the rate and risk factors for EGFR gene mutations on 152 patients with lung adenocarcinoma at Bachmai Hospital. Subjects and methods: 152 patients with lung adenocarcinoma diagnosed by histopathological method; the mutation of EGFR gene was identified by assay Strip methods. Results: 60 lung cancer patients (39.5%) were diagnosed adenocarcinoma. The rate of mutations was found at exons 18, 19, 20, 21 of the EGFR gene. The exon mutations were classified as follows: G719S mutation, G719C (exon 18), LREA deletion (exon 19), T790M (exon 20) and L858R; L861Q (exon 21) were 3.2%, 55.6%, 4.8% and 36.4%, respectively. The possibility of EGFR gene mutations in female patients was 2.9 times as high as male patients (95%CI 1.4 to 6.1) and 3.4 fold higher compared to patients with history of smoking with 95%CI: 1.6 to 6.2. Conclusions: Among 152 patients with lung adenocarcinoma who were treated at Bachmai Hospital, we found the rate of EGFR gene mutations was 39.5%. The mutations of EGFR gene were more common in women and non-smoking patients. * Key words: Lung adenocarcinoma; EGFR gene mutation; Gender; Smoking.