Tóm tắt

Objectives: In this study, the acute toxicity of pidotimod synthesized in Vietnam have been evaluated. Materials are synthetic pidotimod offered by Hanoi University of Pharmacy. Equipments and chemicals used for the study was calibrated according to ISO/IEC 17025. Method: Acute toxicity was evaluated according to the acute toxicity determination method (Medical Publishing House 1996) and the OECD guidelines (OECD guidelines for testing of chemicals. Acute oral toxicity - fixed dose procedure OECD 420, 2001). Results: Acute toxicity of pidotimod by oral administration in mice, LD50 was 22.041 ± 0.649 g/kg. Conclusion: The synthesized pidotimod sample (P120513) belongs to the class of non-toxic substances. * Keywords: Pidotimod; Acute toxicity.

Abstract

Objectives: In this study, the acute toxicity of pidotimod synthesized in Vietnam have been evaluated. Materials are synthetic pidotimod offered by Hanoi University of Pharmacy. Equipments and chemicals used for the study was calibrated according to ISO/IEC 17025. Method: Acute toxicity was evaluated according to the acute toxicity determination method (Medical Publishing House 1996) and the OECD guidelines (OECD guidelines for testing of chemicals. Acute oral toxicity - fixed dose procedure OECD 420, 2001). Results: Acute toxicity of pidotimod by oral administration in mice, LD50 was 22.041 ± 0.649 g/kg. Conclusion: The synthesized pidotimod sample (P120513) belongs to the class of non-toxic substances. * Keywords: Pidotimod; Acute toxicity.