Tóm tắt

Objectives: To study the changes of Hs-CRP, Hs-Troponin T, NT-proBNP level and their relationship with left ventricular diastolic function in patients with unstable angina. Subjects and methods: This study included 125 patients with unstable angina (study group) and 60 healthy people (control group). The participants were taken medical history, physical examination; tested and evaluated left ventricular diastolic function by echocardiography. The control group was performed percutaneous coronary intervention (PCI) and biomarker tests after 3 days. Results: There was no significant difference in age between two groups; p = 0.07. Systolic blood pressure of the study group was higher than that of the control group (p = 0.001). Results of echocardiography had significant differences in some parameters of left diastolic function (left atrium volume index and tricuspid regurgitation velocity) (p < 0.05). Concentration of Hs-Troponin T (9.21 ± 7.73 ng/L) and NT-proBNP (131.01 ± 231.72 pg/mL) of the study group were higher than that of control group (p < 0.05). Plasma NT-proBNP and Hs-CRP levels of the study group increased proportionally with the grades of left ventricular diastolic dysfunction and the degree of left ventricular remodeling. Concentrations of Hs-CRP ≥ 5.0 mg/L and NT-proBNP ≥ 125 pg/mL were not associated with risk of left ventricular diastolic dysfunction (p > 0.05). Conclusions: The concentration of Hs-Troponin T and NT-proBNP in patients with unstable angina were higher than in the control group. Hs-Troponin T and NT-proBNP levels were proportinonally increased with the grades of left ventricular diastolic dysfunction and the degree of left ventricular remodeling. * Keywords: Hs-CRP; Hs-Troponin T; NT-proBNP; Left ventricular diastolic function.

Abstract

Objectives: To study the changes of Hs-CRP, Hs-Troponin T, NT-proBNP level and their relationship with left ventricular diastolic function in patients with unstable angina. Subjects and methods: This study included 125 patients with unstable angina (study group) and 60 healthy people (control group). The participants were taken medical history, physical examination; tested and evaluated left ventricular diastolic function by echocardiography. The control group was performed percutaneous coronary intervention (PCI) and biomarker tests after 3 days. Results: There was no significant difference in age between two groups; p = 0.07. Systolic blood pressure of the study group was higher than that of the control group (p = 0.001). Results of echocardiography had significant differences in some parameters of left diastolic function (left atrium volume index and tricuspid regurgitation velocity) (p < 0.05). Concentration of Hs-Troponin T (9.21 ± 7.73 ng/L) and NT-proBNP (131.01 ± 231.72 pg/mL) of the study group were higher than that of control group (p < 0.05). Plasma NT-proBNP and Hs-CRP levels of the study group increased proportionally with the grades of left ventricular diastolic dysfunction and the degree of left ventricular remodeling. Concentrations of Hs-CRP ≥ 5.0 mg/L and NT-proBNP ≥ 125 pg/mL were not associated with risk of left ventricular diastolic dysfunction (p > 0.05). Conclusions: The concentration of Hs-Troponin T and NT-proBNP in patients with unstable angina were higher than in the control group. Hs-Troponin T and NT-proBNP levels were proportinonally increased with the grades of left ventricular diastolic dysfunction and the degree of left ventricular remodeling. * Keywords: Hs-CRP; Hs-Troponin T; NT-proBNP; Left ventricular diastolic function.